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Vaccines for South Africa

5 vaccines recommended. See what you need, how much it costs, and book online.

Vaccines for South Africa destination photo

Description

South Africa offers Cape Town's Table Mountain, the Garden Route, Kruger National Park safaris, and the winelands of Stellenbosch. No vaccinations are legally required for direct entry from the UK, but Yellow Fever certification is needed if arriving from an endemic country. Malaria is present in the north-east (Kruger, Limpopo, Mpumalanga, KwaZulu-Natal border areas) but absent from Cape Town, Johannesburg, and the Garden Route.

Required Vaccines

These vaccines may be required for entry to South Africa or if transiting through endemic areas.

These vaccines are strongly recommended for travel to South Africa. Our pharmacist will advise which are most relevant to your specific itinerary.

Moderate Risk Level

Malaria in South Africa

Malaria risk is concentrated in the north-eastern provinces: Limpopo, Mpumalanga (including Kruger National Park), and northern KwaZulu-Natal. Risk is highest from October to May (summer/wet season). Cape Town, Johannesburg, Durban city, and the Garden Route are malaria-free. Anti-malarial tablets are recommended for Kruger safaris and north-eastern travel.

Malaria risk illustration for South Africa

Travel Health Tips for South Africa

Practical tips to help you stay safe, healthy, and prepared throughout your trip.

Travel tip 1

  1. If visiting Kruger or the north-east, take malaria tablets as prescribed — start before arrival and complete after returning.

Travel tip 2

  1. Use DEET repellent and long clothing from dusk in malaria areas.

Travel tip 3

  1. Tap water is generally safe in major cities but bottled water is recommended elsewhere.

Travel tip 4

  1. Crime rates are high in some areas — take standard urban precautions and use reputable tour operators.

Travel tip 5

  1. UV levels are very high — sunscreen is essential even on overcast days.

When to Get Vaccinated

Yellow Fever certificate required only if arriving from an endemic country (not needed for direct UK flights). Hepatitis A, Typhoid, and DTP can be given same-day for last-minute travellers. Plan 3–4 weeks ahead for Rabies if visiting Kruger.

Best Time to Visit

May to September (dry winter season — best for safari as animals congregate around water sources). Cape Town and the Western Cape are best December to March (summer). October to May is the malaria risk season in the north-east.

UK Government Health Advice

Official recommendations from UK health authorities for travel to South Africa. Always consult a healthcare professional for advice tailored to your specific itinerary.

NaTHNaC TravelHealthPro — South Africa

“A Yellow Fever vaccination certificate is required from travellers over 1 year of age arriving from countries with risk of Yellow Fever transmission.”


Accessed April 2026

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